Peptide Publications Archive
ACE-Inhibitory Peptides
Beys-da-Silva Lab
Hypertension remains the leading cause of premature death worldwide, yet one in five affected adults achieve adequate blood pressure control. Angiotensin-converting enzyme inhibitors represent one …
Programmable Peptide Coacervates
Tian Group
Peptide-based coacervates have emerged as versatile platforms for drug delivery, tissue scaffolding, bioreactor systems, and cellular regulation due to their sequence programmability, dynamic self-assembly, and …
Chiral Prodrug Synthesis
Kong Lab
Carboxylic acid groups frequently serve as essential pharmacophores in drug molecules, yet their high polarity limits membrane permeability and can reduce bioavailability. Prodrug strategies address …
Computational Peptide Design
Guo Group
Xanthine oxidase catalyzes the final steps of purine catabolism, converting hypoxanthine and xanthine to uric acid. Dysregulation of this enzyme leads to excessive uric acid …
Photocatalytic Carboxylation
Wang Group
α-Amino acids serve as the fundamental building blocks of peptides and proteins while also functioning as precursors for natural products and catalysts. Synthesizing unnatural amino …
Conditional Miniprotein Activation
Oller-Salvia Lab
Protein therapeutics have transformed treatment of diseases from cancer to immune disorders, yet many targets appear not only at diseased sites but also in healthy …
Nitrogen Walks
Huang/Xiao Labs
Noncanonical amino acids have become indispensable tools in chemical biology and drug discovery. By introducing side chains that nature never encoded, researchers can endow peptides …
Beyond Alpha
Ohshima/Yazaki Labs
Unnatural amino acids have transformed both medicinal chemistry and chemical biology. By introducing side chains that nature never encoded, chemists can enhance metabolic stability, tune …
Clicking Safely
Jain Lab
The 1,2,3-triazole ring has become indispensable in peptidomimetic design. Its geometry and electronic properties closely mimic the trans-amide bond: similar planarity, comparable dipole moment, and …
Catching Lanthanides
Zeymer Lab
Lanthanide ions offer an extraordinary toolkit for biomolecular engineering. Their long-lived luminescence enables sensitive detection, their paramagnetism provides NMR structural probes, their strong anomalous X-ray …
Designing Droplets
Pina Lab
Cells organize their interiors not only with membranes but also through liquid-liquid phase separation, LLPS, the spontaneous demixing that creates membraneless organelles like nucleoli and …
Binders by Design
Pomplun Lab
Discovering high-affinity ligands directly from protein structures has long tantalized drug discovery scientists. Virtual screening can explore billions of small molecules computationally, yet hit rates …