Synthetic peptides derived from naturally occurring host defence peptides, HDPs, have garnered significant attention as novel pharmaceuticals, particularly as alternatives to antibiotics and for immunomodulatory applications. One of the barriers to advancing synthetic peptides...

To combat the serious issue of increasing global antibiotic resistance, new antimicrobial therapies are urgently required. As one alternative, previously used antibiotics are...

In coiled-coil, CC, protein structures α-helices wrap around one another to form rope-like assemblies. Most natural and designed CCs have two-four helices...

Published in Peptide Science, researchers in Shelli McAlpine's lab describe the design, synthesis, and biological evaluation of 5 N-methylated analogs that are based on a lead drug structure...

Cell penetrating peptides, CPPs, are frequently used to deliver peptide cargo into cells where they can exert their biological activity. Their success, however, can be dependent on the cargo, the cell type, and other...

Due to their unique characteristics, which are not shared by canonical α-peptides, peptides that contain stretches of consecutive β-amino acids are attractive scaffolds for novel peptide drugs and nanomaterials...