This colloborative work between the Garner and Kritzer labs shows their continued efforts to develop and characterization of a cell-penetrant lactam stapled peptide for targeting cellular eIF4E...

Researchers at the University of Sydney have shown that the evasin protein ACA-01 from the Amblyomma cajennense tick can be posttranslationally sulfated at two tyrosine residues...

This publication shows that micelle-assisted reaction can facilitate native chemical ligations between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety...

Herein is reported an operationally simple method to facilitate chemical protein synthesis by fully convergent and one-pot native chemical ligations...

This recently published review discusses the current status of the peptide drugs targeting G protein-coupled receptors (GPCRs), with a focus on evolving strategies...

Researchers report a simple reductive amination protocol to ligate two peptides, while simultaneously installing a β-turn mimic at the ligation junction...

Teixobactin is a nonribosomal antibiotic peptide that inhibits the biosynthesis of peptidoglycan and teichoic acid, however, teixobactin’s cellular site of action is unknown...

Guéret and colleagues describe a versatile method for inserting chiral motifs between the ends of omega loops. Peptides are synthesized using traditional SPPS...

This case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, is a cautionary note for researchers who handle peptide coupling agents frequently...