Teixobactin is a nonribosomal antibiotic peptide that inhibits the biosynthesis of peptidoglycan and teichoic acid, however, teixobactin’s cellular site of action is unknown...

Guéret and colleagues describe a versatile method for inserting chiral motifs between the ends of omega loops. Peptides are synthesized using traditional SPPS...

This case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, is a cautionary note for researchers who handle peptide coupling agents frequently...

In this collaborative study, researchers have designed a new generation of peptides based on previously designed cyclic cell-penetrating peptides. They have evaluated their cytotoxicity as well as uptake behavior...

In this recent publication, Puhl et al. have employed random peptide phage display to screen and select peptides that bind to the calcium and integrin binding protein 1 (CIB1)...

The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly...

In this study, the recently developed chloroalkane penetration assay was combined with established assays to characterize the cellular uptake and cytosolic delivery of the prototypic cyclotide, kalata B1...

In this recent Science publication, Hartrampf et al. report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing of peptide chains up to 164 amino acids long...

In this manuscript researchers in Dr. Craik's lab describe a strategy to improve the production of cyclotides, which are usually produced and cyclized synthetically at a high cost and environmental impact for large scale.