A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Published in ACS Chemical Biology, and presented...

Ring-closing metathesis, RCM, is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected...

Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications...

Somatostatin, SS, is a cyclic tetradecapeptide able to inhibit the release of growth hormone, GH, mainly through the binding to two G‐protein coupled...

In a manuscript published in Langmuir, Yuki Kamijo and Ratmir Derda from the, University of Alberta, describe a screening system that employs the difference...

Trans amide bonds and fast cis–trans isomerization of Xaa-Pro bonds are crucial for the stability and folding rate of collagen, the most abundant protein in mammals...

Ribosomally synthesized and post-translationally modified peptides, RiPPs, are ubiquitous natural products. Bioactive RiPPs are produced from a precursor...

Liquid-like droplets of biomacromolecules are emerging as a fundamental mechanism of cellular signaling, but designing synthetic mimics to form such...

Aza‐propargylglycine, azaPra, peptides are branching points for the synthesis of azapeptide libraries. Researchers in the Lubell Lab, published in...