Ra Pharmaceuticals, Inc., has announced that it has received a development milestone payment under its collaboration agreement with Merck, known as MSD outside the US and Canada. The milestone payment is associated with the companies' collaboration...

In coiled-coil, CC, protein structures α-helices wrap around one another to form rope-like assemblies. Most natural and designed CCs have two-four helices...

Published in Peptide Science, researchers in Shelli McAlpine's lab describe the design, synthesis, and biological evaluation of 5 N-methylated analogs that are based on a lead drug structure...

Cell penetrating peptides, CPPs, are frequently used to deliver peptide cargo into cells where they can exert their biological activity. Their success, however, can be dependent on the cargo, the cell type, and other...

Due to their unique characteristics, which are not shared by canonical α-peptides, peptides that contain stretches of consecutive β-amino acids are attractive scaffolds for novel peptide drugs and nanomaterials...

Macrocyclic peptides are capable of binding to flat protein surfaces such as the interfaces of protein-protein interactions with antibody-like affinity and specificity, but generally lack cell permeability...