Herein is a review of ongoing research aimed at developing constrained peptides targeting protein-protein interactions pertinent to malaria pathogenesis.

The ubiquitin–proteasome system (UPS) is a highly regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be an effective cancer treatment.

In a larger collaborative effort, these researchers have combined the strategies to identify the first examples of all-D α-helical stapled and stitched peptides.

Herein, a noninteracting multiphase molecular assembly approach is developed to crystallize tofacitinib, a potent JAK1/3 inhibitor, within a shearthinning self-assembled fibrillar peptide hydrogel network...

Church et al. report a tunable chemical genetics approach for enhancing genetic code expansion in different wild-type bacterial strains..

Abundant n → π* interactions between adjacent backbone carbonyl groups are predicted to play an important role in dictating the structure of proteins...

Herein, Wang et al. present a photoredox-catalyzed asymmetric method for the preparation of enantiopure β-thiolated/selenolated amino acids using a simple chiral auxiliary...

Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of diagnostic tools...

In this review, the researchers summarize peptide and peptide based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...