Ra Pharmaceuticals, Inc., has announced that it has received a development milestone payment under its collaboration agreement with Merck, known as MSD outside the US and Canada. The milestone payment is associated with the companies' collaboration...

Most native producers of ribosomally synthesized and post-translationally modified peptides, RiPPs, utilize N-terminal leader peptides to avoid potential cytotoxicity of mature products to...

Allosteric enzymes contain a wealth of catalytic diversity that remains distinctly underutilized for biocatalysis. Tryptophan synthase is a model allosteric system and a valuable enzyme...

In work published in Angewandte Chemie, researchers in the Wennemers Group present functionalized proline-rich peptides that bind c-di-GMP in aqueous solution. They also show that the functionalized...

Natural product discovery has been at the root of modern drug design, and it continues to play a vital role as there is renewed focus on orally available peptide therapeutics. In particular, macrocyclic peptides...

Amphipathic peptides with alternating polar and nonpolar amino acid sequences efficiently selfassemble into functional β-sheet fibrils as long as the nonpolar residues have sufficient hydrophobicity...