Peptide Publications Archive
Peptides on Demand
Chatterjee Lab
Antibodies dominate biochemical research, but their context-dependent performance, reproducibility problems, and opaque binding determinants leave scientists wanting better tools. A new review from the Chatterjee …
Function-First Macrocycles
Suga Lab
A new cell-based mRNA display platform bypasses affinity-only screening to discover a macrocyclic insulin receptor agonist that conventional methods would have missed...
Lighting Up Oligomers
Tonali Lab
A cyclopeptide-BODIPY conjugate built from Alzheimer's own amyloid sequence outperforms antibodies at spotting toxic prefibrillar aggregates inside neurons
Stabilizing Pseudouridimycin
Del Valle Group
Cryo-EM guided solid-phase synthesis yields 50 stabilized pseudouridimycin analogs, including a para-phenyl amidine that inhibits bacterial RNA polymerase fourfold better than the parent compound
Beyond the Membrane
Marcotte Lab
Researchers supervised by Professor Isabelle Marcotte at the Université du Québec à Montréal, published in J. Am. Chem. Soc., investigated three amphibian-derived AMPs with …
Activating Dehydroalanine
Liu and Wang Groups
A previously overlooked deprotonation of the dehydroalanine amide N–H unlocks selective arylation of peptides under mild conditions, with no metal catalyst required
Backbone Sensitivity
Cate & Schepartz Groups
Researchers in the Cate and Schepartz Groups at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory, published in the Journal of the …
Leaderless Death Caps
Pringle, Keller, & Drott Labs
Researchers in the Pringle and Keller Groups at the University of Wisconsin-Madison, published in PNAS, combined chemistry-guided metabolite isolation with an updated bioinformatic pipeline …
Bismuth Bicycles
Spring Group & Bicycle Therapeutics
Researchers in the Spring Group at the University of Cambridge, working in collaboration with Bicycle Therapeutics, explored bismuth(III) as an alternative scaffold for bicyclic peptide …
Scaling Azapeptides
Lubell Lab
A resonant acoustic mixing strategy solves long-standing problems in azapeptide synthesis, delivering scalable aza-tripeptide building blocks without epimerization, hydantoin formation, or chromatographic purification
Amide Proteome Mapped
Raj Lab
A palladium-mediated dehydration reaction converts asparagine and glutamine amides to nitriles, opening nearly 9% of the human proteome to chemoproteomic interrogation for the first time...
Silent Residues, Activated
Raj Lab
Asparagine and glutamine make up over 8% of the human proteome yet resist chemical modification — until now, when a palladium-mediated strategy converts their amide …
Backbone Bonds Unlocked
Del Valle Lab
A backbone hydroxamate group enables sequence-agnostic peptide ligation in water, bypassing thiolated amino acids and opening convergent routes to folded miniproteins and macrocyclic natural products
Masked Magainin
Lee Lab
Researchers supervised by Professor Hsien-Ming Lee at the Institute of Chemistry, Academia Sinica, Taipei, Taiwan, published in J. Am. Chem. Soc., screened nine cationic …
Switching Ligation Directions
Hayashi Lab
Researchers in the Hayashi, Murakami, and Okamoto Groups at Nagoya University and the University of Tokyo, published in the Journal of the American Chemical Society …
Light-Driven Ligation
Taylor Lab
A fully organic photosensitizer pair labels proteins inside living cells with 93% selectivity for tryptophan, reaching nuclear compartments without any metal catalyst
Helical Hierarchy
Xiao Lab
Researchers supervised by Professor Shiyan Xiao at the University of Science and Technology of China in Hefei, published in J. Am. Chem. Soc., studied …
Coaxing New Vessels
Choi Lab
An AI-designed peptide mimics VEGF's receptor-activating power, accelerating wound closure in diabetic mice and raising hopes for a stable, tunable pro-angiogenic therapy
Losing the Charge
Pei Lab
A bicyclic peptide carrying just a +2 charge outperforms its highly cationic parent, upending the dogma that cell-penetrating peptides need dense positive charge to work
Templated Macrocycles
Wennemers Group
Researchers in the Wennemers Group at ETH Zürich, published in Science, developed a bifunctional tripeptide catalyst that templates head-to-tail macrocyclization through dual substrate engagement
Designing Peptide Materials
López-Silva Group
Synergistic peptide cues, structural conformation, and stimulus-responsive chemistries let materials recapitulate the dynamic complexity of native tissue microenvironments
Peptoid Ligation
Kirshenbaum Group
Researchers adapt native chemical ligation to peptoid oligomers, enabling convergent synthesis of sequence-defined macromolecules and functional nanomaterials
Crystals Deliver Cargo
Chmielewski Lab
Ni(II)-assembled coiled-coil peptide nanocrystals pack hundreds of folded proteins and, when decorated with a TAT peptide, triple their intracellular delivery efficiency
Rippled Sheets
Nilsson Group
Enantiomeric peptide mixtures preferentially form rippled β-sheets over pleated structures, expanding design principles for next-generation biomaterials