Peptide Publications Archive
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Antibody Drug Painting
Pentelute Group
Researchers in the Pentelute Group at the Massachusetts Institute of Technology, collaborating with several other institutes and groups at MIT, published in Chem, have …
Dual Targeting Dendrimers
Alderete & Jiménez Labs
Tumor blood vessels differ from healthy vasculature in ways that drug developers can exploit. Endothelial cells lining tumor vessels overexpress E-selectin, a glycoprotein normally involved …
Fluorinated Viral Mimics
Matsuura Lab
Messenger RNA therapeutics have transformed medicine, from vaccines against infectious diseases to emerging applications in cancer immunotherapy and genome editing. Unlike DNA-based treatments that require …
Mirrored for Stability
Luo Lab
T-cell immunoglobulin and mucin domain 3, TIM-3, ranks among the most promising immune checkpoint targets in oncology. Expressed on exhausted T cells, natural killer cells, …
Cytosolic Delivery
Beck-Sickinger Lab
Therapeutic peptides offer a powerful strategy for disrupting intracellular protein-protein interactions that small molecules cannot effectively target. However, delivering peptides to the cytosol presents a …
Crossing Cell Barriers
Meldal Lab
The cell membrane stands as biology's most formidable gatekeeper. Large molecules, from therapeutic proteins to diagnostic agents, cannot simply walk through. This barrier has frustrated …
Ephemeral Pores
Pastor Lab
In a PNAS study, researchers from the Pastor group at the National Institutes of Health, NIH, and the Cotten group at Oregon State University present …
Mitochondrial Click
Wennemers Lab
In work published in ACS Chemical Biology, Adeline Schmitt, under the guidance of Helma Wennemers at ETH Zürich, investigated rigid polyproline II, PPII, helical …
Targeted Conjugates
Zeglis Lab
For two decades, immunoconjugates have been a mainstay of targeted oncology, from antibody–drug conjugates to radioimmunotherapy probes. The clinical challenge has never been the underlying …
Delivery of Peptide-LYTAC
Luan Lab
While immune checkpoint blockade, ICB, therapies have transformed cancer immunotherapy, tumors such as melanoma frequently exploit the CD47-SIRPα axis to evade macrophage-mediated clearance. Antibody-based CD47 …
Intracellular Targeting
Futaki Lab
The delivery of biomacromolecules directly into the cytosol remains a central challenge in therapeutic peptide science. Coacervate-based systems offer a promising platform, yet many are …
Efficient siRNA Delivery
Anders Lab
In this collaborative study, published in Bioconjugate Chemistry by researchers from the Dahlén group at Astra-Zeneca, Gothenburg, Sweden, and the Andaloussi team at the Karolinska …