Peptide Publications Archive
Showing items in Peptide Design · Clear filter
Frankenprotein Precision
Shin Lab
Researchers in the Shin Group at Chapman University, published in ACS Synthetic Biology, drew inspiration from an unusual source: the homeodomain-leucine zipper transcription factor …
Budding Immunity
Mayo Group
Immune cells naturally release extracellular vesicles studded with peptide-MHC complexes that can orchestrate immune responses, either directly stimulating T cells or transferring their cargo to …
Mapping Membrane Activity
Hennig & Nau Labs
Cell-penetrating peptides and antimicrobial peptides both interact with lipid membranes, but with fundamentally different outcomes. Cell-penetrating peptides slip through membranes while leaving them largely intact, …
Targeted Evolution
Jumi Shin Lab
Rational protein design can create remarkable molecules, but it explores only a sliver of sequence space. The Shin group at the University of Toronto has …
Computational Peptide Design
Guo Group
Xanthine oxidase catalyzes the final steps of purine catabolism, converting hypoxanthine and xanthine to uric acid. Dysregulation of this enzyme leads to excessive uric acid …
Binders by Design
Pomplun Lab
Discovering high-affinity ligands directly from protein structures has long tantalized drug discovery scientists. Virtual screening can explore billions of small molecules computationally, yet hit rates …
β-Hairpin Oligomers
Nowick Lab
Researchers in the Nowick Group at the University of California Irvine, reveal how a designed β-hairpin peptide derived from amyloid-β, Aβ, crosses the boundary from …
TCR Peptide Design
Nourmohammad Lab
In work published in PNAS, Visani and colleagues from the University of Washington, introduce a structure-aware machine learning approach that forecasts TCR–peptide–MHC interactions and …
Docking Bias
Keating Lab
Deep-learning structure predictors now place many peptides correctly onto their protein partners, and this recent work from Lindsey Guan and Amy Keating at the Massachusetts …
Helical Hydrazides
Gellman Lab
Seeking to understand the relative kinetic benefits of reactive unit connection and preorganization, researchers from the Gellman Lab at the University of Wisconsin–Madison investigated α/β-peptide …
Azapeptoid Collagen
Del Valle Lab
Collagen’s mechanical grace comes from a deceptively simple code: repeating Gly-Xaa-Yaa triplets that assemble into three left-handed PPII chains winding into a right-handed triple helix. …
Stapled Sheets
Del Valle Lab
The stabilization of β-sheet structures has long been a challenge in peptide design, despite their central role in mediating protein–protein interactions, PPIs. While side-chain …
Conformational Equilibrium
Serianni Lab
The conformational behavior of alanine dipeptide, Ac-L-Ala-NHMe, 1, has long made it a model compound in molecular simulation studies. However, despite numerous …
Proline Scanning
Wu Lab
Disulfide-rich peptides, DRPs, are renowned for their stability and therapeutic promise, yet their natural structures offer limited flexibility for evolution or functional adaptation. In an …
Rational Design
Gellman Lab
The rational construction of stable hetero-oligomeric protein complexes with defined subunit composition is a central challenge in molecular design. In this study, published in the …
Grafted Coiled Coils
Andrew J. Lab
Protein–protein interactions, PPIs, are fundamental to cellular regulation, yet targeting them therapeutically remains challenging due to their extensive, shallow interfaces. Peptides offer an attractive solution, …
Sequence Architecture
Woolfson Lab
The Woolfson Lab continues to break new ground in de novo protein design with the successful creation of mixed-charge A3B3 heterohexameric α-helical …
Dynamic Ion Channels
Niitsu Lab
Membrane-spanning peptides that form ion-conductive channels remain a challenging frontier in de novo protein design. While strides have been made in creating water-soluble peptide assemblies, …
Protein Design
Tezcan Lab
Isopeptide bonds, IPBs, — covalent linkages between the side chains of lysine and asparagine/glutamine or aspartate/glutamate — are remarkable for their chemical resilience and structural …
Molecular Flasks
Woolfson Lab
To address the formidable challenge of binding and orienting multiple small molecules for directed chemical reactions, researchers in the Woolfson and Oliver groups at the …