Peptide Publications Archive
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Computational Peptide Design
Guo Group
Xanthine oxidase catalyzes the final steps of purine catabolism, converting hypoxanthine and xanthine to uric acid. Dysregulation of this enzyme leads to excessive uric acid …
Conditional Miniprotein Activation
Oller-Salvia Lab
Protein therapeutics have transformed treatment of diseases from cancer to immune disorders, yet many targets appear not only at diseased sites but also in healthy …
Binders by Design
Pomplun Lab
Discovering high-affinity ligands directly from protein structures has long tantalized drug discovery scientists. Virtual screening can explore billions of small molecules computationally, yet hit rates …
β-Hairpin Oligomers
Nowick Lab
Researchers in the Nowick Group at the University of California Irvine, reveal how a designed β-hairpin peptide derived from amyloid-β, Aβ, crosses the boundary from …
TCR Peptide Design
Nourmohammad Lab
In work published in PNAS, Visani and colleagues from the University of Washington, introduce a structure-aware machine learning approach that forecasts TCR–peptide–MHC interactions and …
Docking Bias
Keating Lab
Deep-learning structure predictors now place many peptides correctly onto their protein partners, and this recent work from Lindsey Guan and Amy Keating at the Massachusetts …
Helical Hydrazides
Gellman Lab
Seeking to understand the relative kinetic benefits of reactive unit connection and preorganization, researchers from the Gellman Lab at the University of Wisconsin–Madison investigated α/β-peptide …
Azapeptoid Collagen
Del Valle Lab
Collagen’s mechanical grace comes from a deceptively simple code: repeating Gly-Xaa-Yaa triplets that assemble into three left-handed PPII chains winding into a right-handed triple helix. …
Stapled Sheets
Del Valle Lab
The stabilization of β-sheet structures has long been a challenge in peptide design, despite their central role in mediating protein–protein interactions, PPIs. While side-chain …
Conformational Equilibrium
Serianni Lab
The conformational behavior of alanine dipeptide, Ac-L-Ala-NHMe, 1, has long made it a model compound in molecular simulation studies. However, despite numerous …
Proline Scanning
Wu Lab
Disulfide-rich peptides, DRPs, are renowned for their stability and therapeutic promise, yet their natural structures offer limited flexibility for evolution or functional adaptation. In an …
Rational Design
Gellman Lab
The rational construction of stable hetero-oligomeric protein complexes with defined subunit composition is a central challenge in molecular design. In this study, published in the …