Peptide Publications Archive
Showing items in Natural Products & Biosynthesis · Clear filter
Leaderless Death Caps
Pringle, Keller, & Drott Labs
Researchers in the Pringle and Keller Groups at the University of Wisconsin-Madison, published in PNAS, combined chemistry-guided metabolite isolation with an updated bioinformatic pipeline …
Split Lasso Discovery
Seyedsayamdost & Moon Groups
Marine actinomycete produces anticancer lasso peptides from a split biosynthetic gene cluster separated by over 2 million base pairs.
Convergent Bradykinin Mimicry
Robinson Lab
Researchers in the Robinson Group at the University of Queensland, published in Science, demonstrated that bradykinin-like peptides found in hymenopteran venoms and anuran skin …
Jujube Unlocked
Kersten Lab
Researchers in the Kersten Group at the University of Michigan, published in J. Am. Chem. Soc., identified candidate biosynthetic genes in the genome of …
Ginkgo Degrader
Tam Lab
Researchers in the Tam Group at Nanyang Technological University identified a hyperdisulfide-constrained peptide from Ginkgo biloba nuts, termed β-ginkgotide β-gB1, as a first-in-class
Oxidative Backbone Cleavage
van der Donk Lab
Researchers in the van der Donk Group at the University of Illinois Urbana-Champaign, published in the Journal of the American Chemical Society, used genome …
Uniform Cleavage
Phan Lab
Researchers in the Phan Group at the Latvian Institute of Organic Synthesis, published in Communications Chemistry, have characterized a serine protease that cleaves precursor …
Leader-Dependent Prenylation
Agarwal Lab
Lipidation of macrocyclic peptides represents a pharmaceutically important chemical transformation. Adding lipid groups to peptides can enhance antibiotic activity, alter membrane transport properties, and improve …
NRPS Golden Gate
Bode Lab
A modular Golden Gate–based workflow unites the XUT concept with non-ribosomal peptide synthetase engineering, enabling rapid, scarless assembly of hybrid enzymes. Over 100 constructs yielded …
Alkyne Grasp
Fujishiro Lab
ATP-grasp ligases offer a powerful route to diversify peptide structures, and BesA stands out for its ability to incorporate terminal alkyne groups into dipeptides with …
Lanthipeptide Modeling
Walker Lab
Lanthipeptides, the thioether-crosslinked members of the RiPP family, are compelling antibiotic scaffolds. Yet, they have remained largely outside the reach of structure-based design. Standard modeling …
Macrocyclic Peptide Antibiotics
van der Donk Lab
Ribosomally synthesized and posttranslationally modified peptides, RiPPs, represent one of the most structurally diverse classes of natural products, yet many RiPP families remain biosynthetically uncharacterized...
Potent Antifungal Lipopeptide
Süssmuth Lab
In this study, researchers from the Süssmuth group at the Technische Universität Berlin, published in the Journal of the American Chemical Society, elucidated the …
Peptide Modifications
Phan Lab
Ribosomally synthesized and post-translationally modified peptides, RiPPs, represent an expanding class of natural products distinguished by their extensive post-translational modifications. Among the enzymatic systems...
Genome Mining
Agarwal Lab
Brominated intermediates have long been favored in organic synthesis for their chemical versatility, particularly in transition-metal-assisted bond-forming reactions. The Agarwal and van der Donk study …
Graspetides
Ding Lab
Published in ACS Chemical Biology, researchers in the Ding Group at the University of Florida, reconstructed prunipeptin biosynthesis from Streptomyces coelicolor...