Peptide Publications Archive
Showing items in Cyclic Peptides · Clear filter
Function-First Macrocycles
Suga Lab
A new cell-based mRNA display platform bypasses affinity-only screening to discover a macrocyclic insulin receptor agonist that conventional methods would have missed...
Bismuth Bicycles
Spring Group & Bicycle Therapeutics
Researchers in the Spring Group at the University of Cambridge, working in collaboration with Bicycle Therapeutics, explored bismuth(III) as an alternative scaffold for bicyclic peptide …
Charged Ring Entry
Kodadek Group
Grafting a permanent positive charge onto macrocyclic peptides drives passive membrane crossing in minutes, transforming a membrane-impermeable p53–MDM2 antagonist into a bioactive inhibitor without mitochondrial …
Intracellular Peptide Stapling
Mason Lab
Researchers in the Mason Group at the University of Bath, published in Cell Chemical Biology, developed a platform called intracellular-cyclization TBS that merges chemical …
Lasso Peptide Progress
Craik Lab
In a new Perspective published in the Journal of the American Chemical Society, Professor David J. Craik and colleagues at the University of Queensland's …
Mimicking Nature's Grip
Mott and Owen Lab
Researchers supervised by Drs. Helen Mott and Darerca Owen at the University of Cambridge, published in Biochemistry, engineered a new generation of disulfide-cyclized peptide …
Cyclic Cell Anchors
Yamada Group
Researchers in the Yamada Group at Tokyo University of Pharmacy and Life Sciences, published in Biochemistry, have systematically characterized LDV-derived peptides as cell-adhesive molecules …
Ribosomal Bicycles
Suga Lab
Bicyclic peptides occupy a sweet spot in drug discovery. Their constrained architectures resist proteolytic degradation and bind targets with antibody-like specificity, yet they remain small …
Photoclick Bicycles
Lei Lab
Bicyclic peptides offer exceptional promise for targeting protein-protein interactions, combining the conformational rigidity needed for high-affinity binding with improved metabolic stability. Yet their construction remains …
Ultrafast Peptide Cyclization
Sun Lab
Cyclic peptides occupy a privileged niche in chemical biology. Their constrained conformations reduce entropic penalties upon binding, impart proteolytic stability, and frequently enable access to …
Molecular Scaffolds
Craik Lab
This comprehensive review from the labs of David Craik and Lara Malins at Australian Research Council Centre of Excellence for Innovations in Peptide and Protein …
Enlicitide Decanoate
Thaisrivongs Lab
The total synthesis and process development of enlicitide decanoate, MK-0616, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9, PCSK9, represents a major breakthrough …
Selective Cyclization
Liu Lab
To address the limitations of current methods for peptide macrocyclization, which often rely on nonspecific small-molecule linkers...
Yeast CICLOPPS
Knudsen Lab
Researchers in the Knudsen Group at the University of Aarhus, Denmark, published in Biochemistry, report the construction of a Saccharomyces cerevisiae-specific SICLOPPS library …