Peptide Publications Archive
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Chiral Prodrug Synthesis
Kong Lab
Carboxylic acid groups frequently serve as essential pharmacophores in drug molecules, yet their high polarity limits membrane permeability and can reduce bioavailability. Prodrug strategies address …
Photocatalytic Carboxylation
Wang Group
α-Amino acids serve as the fundamental building blocks of peptides and proteins while also functioning as precursors for natural products and catalysts. Synthesizing unnatural amino …
Clicking Safely
Jain Lab
The 1,2,3-triazole ring has become indispensable in peptidomimetic design. Its geometry and electronic properties closely mimic the trans-amide bond: similar planarity, comparable dipole moment, and …
Taming Aggregation
Hartrampf Lab
Peptide chains misbehave. During solid-phase peptide synthesis, growing chains can collapse into sticky β-sheet structures that clog the resin, block coupling reactions, and leave chemists …
Acoustic Coupling
Lubell Group
The demand for peptide therapeutics is booming, but their manufacture carries a heavy environmental burden. Solid-phase peptide synthesis, SPPS, the workhorse of the field, consumes …
Masked Sugars
Dong Lab
Chemical synthesis provides atomic-level control over glycoprotein structure, yet hydrophobic sequences often aggregate before chemists can purify or ligate them. This problem may intensify for …
Phosphine Rebridging
Hackenberger Lab
Published in Angewandte Chemie International Editition, researchers from the Hackenberger Lab at the Humboldt-Universität in Berlin, present a powerful new class of phosphine oxide–based …
Copper Clicks
Metanis Lab
In a collaborative work between the Metanis and Shimon labs at the Hebrew University of Jerusalem, and the Wang group at the Xiamen University in …
Cysteine Umpolung
Wang Lab
A longstanding challenge in peptide chemistry has been the restricted reactivity of canonical amino acids, which limits late-stage functionalization strategies. Most side chains are inherently …
Rewiring the Protein Backbone
Schepartz Lab
Backbone editing offers a powerful way to expand protein function: by introducing β, γ, or δ linkages, researchers can strengthen folds against proteolysis, reshape ligand …
Oxidative Peptide Coupling
Proulx Lab
This study demonstrates that a key determinant of this reactivity is the choice of solvent. By shifting from aqueous buffer to a mixed organic solvent …
Versatile Precursors
Mitchell Lab
Cyclopropane-containing amino acids, prized for their conformational rigidity and stability, are of increasing interest in therapeutic peptide development and antimicrobial drug discovery. A recent study …