Peptide Publications Archive
Showing items in Chemical Biology · Clear filter
Cooperativity Unlocked
Waters Lab
Christopher Travis, and colleagues in Marcey Waters' laboratory at the University of North Carolina, published in Biochemistry, devised an elegant strategy to probe why …
Quantifying S-Acylation
Thinon Group
Researchers in the Emmanuelle Thinon Group at the University of Bordeaux, published in ACS Chemical Biology as part of the special issue "Lipids and Lipidation," …
Nitrogen Walks
Huang/Xiao Labs
Noncanonical amino acids have become indispensable tools in chemical biology and drug discovery. By introducing side chains that nature never encoded, researchers can endow peptides …
Catching Lanthanides
Zeymer Lab
Lanthanide ions offer an extraordinary toolkit for biomolecular engineering. Their long-lived luminescence enables sensitive detection, their paramagnetism provides NMR structural probes, their strong anomalous X-ray …
Guided Precision
Waser Lab
Cysteine residues attract chemical attention. Their nucleophilic thiol groups react readily with electrophiles, making them popular handles for attaching drugs, fluorophores, and other payloads to …
Borrowed Machinery
Xu Lab
N-myristoylation is a common posttranslational modification in which the enzyme N-myristoyltransferase, NMT, attaches a 14-carbon fatty acid to an N-terminal glycine residue. This lipid anchor …
Optimizing Peptide Switches
Maly Lab
Chemically-controlled genetic tools allow researchers to switch cellular processes on or off with small molecules, offering precise temporal and dose-dependent control. While chemically-inducible dimerization systems …
Taming Arginine
Raj Lab
Selective modification of amino acid side chains has become a central strategy for expanding peptide function beyond the limits of ribosomal chemistry. Yet one residue …
Iodo Quantification
Lilienkampf Lab
In work published in ACS Chemical Biology, David J. Clarke, Annamaria Lilienkampf, and collaborators from the University of Edinburgh, introduce an iodo based labeling strategy …
Dilp Divergence
Bland Lab
Insulin-like peptides orchestrate how animals apportion nutrients between storage and growth, yet distinct ligands may encode different cues even when signaling through a single receptor. …
Affinity Landscapes
Bussemaker Lab
A collaborative study from the Bussemaker and Shah Groups at Columbia University, published in Protein Science, establishes an integrated experimental–computational framework, built on massively …
Serine Switch
Diao Lab
Published in the Journal of the American Chemical Society, work by first author Zhenyan Guo in the Diao Lab at the New York University, …
Photoregulated Catalysis
Bandyopadhyay Lab
Precise external regulation of enzymatic activity remains a central goal in chemical biology, with wide-ranging implications for biotechnology, diagnostics, and medicine. Natural proteases govern countless …
Spike Peptide Amyloids
Legleiter Lab
SARS-CoV-2 spike protein fragments are known to form amyloid fibrils, but far less is understood about the prefibrillar states that emerge along the way, or …
HDAC-Mediated Lactylation
Goldberg Lab
Lysine lactylation, Kla, has emerged as a post-translational modification, PTM, directly linking glycolytic metabolism to protein regulation. While earlier models invoked lactyl-CoA–dependent transfer or non-enzymatic …
Peptide Galanin Binding
Patnaik Lab
In a landmark study, published in ACS Chemical Biology, researchers from the Samarjit Patnaik group at the National Institutes of Health, report the development …
Protein Phosphorylation
Köhn Lab
Professor Maja Köhn took the stage at the 29th American Peptide Symposium in San Diego, her presentation, "Targeting Phosphatases with Peptides and Phosphomimetics," offered a …
Ubiquitin Azapeptide Esters
Liu Lab
Published as an ASAP article in the Journal of the American Chemical Society, researchers from the Wenshe Liu Lab at Texas A&M, currenly our …
Arginine Carbonylation
Raj Lab
The selective incorporation of post-translational modifications, PTMs, into proteins remains a key challenge in chemical biology, particularly for modifications like arginine carbonylation, which plays a …
Electrophilic Warheads
Research Lab
Understanding how proteins interact with biological metabolites is crucial for deciphering biological processes and advancing therapeutic strategies. This study focuses on a specific class of …
Super-Res Microscopy
Guha Lab
Researchers in the Samit Guha Group at Jadavpur University, Kolkata, India, published in Bioconjugate Chemistry, report a groundbreaking approach to cancer imaging...