Peptide Publications Archive
Showing items in Drug Discovery · Clear filter
Peptides on Demand
Chatterjee Lab
Antibodies dominate biochemical research, but their context-dependent performance, reproducibility problems, and opaque binding determinants leave scientists wanting better tools. A new review from the Chatterjee …
Lighting Up Oligomers
Tonali Lab
A cyclopeptide-BODIPY conjugate built from Alzheimer's own amyloid sequence outperforms antibodies at spotting toxic prefibrillar aggregates inside neurons
Stabilizing Pseudouridimycin
Del Valle Group
Cryo-EM guided solid-phase synthesis yields 50 stabilized pseudouridimycin analogs, including a para-phenyl amidine that inhibits bacterial RNA polymerase fourfold better than the parent compound
Triple Receptor Agonism
DiMarchi Group
An engineered triple agonist targeting FGF21, GLP-1, and GIP receptors achieves near normalization of body weight in obese mice.
Myeloma in Focus
Shokeen Group
Researchers in the Shokeen Group at Washington University in St. Louis, published in Bioconjugate Chemistry, identified a novel CD38-binding peptide sequence, HAPWFRGGGGS, through phage …
Targeting Protein Interactions
Arora Lab
Researchers in the Arora Group at New York University, published in Chemical Reviews, have assembled a comprehensive blueprint for designing inhibitors of protein-protein interactions. …
Metabolic Resilience
Labs at Genentech
Researchers at Genentech, published in the Journal of Medicinal Chemistry, present a comprehensive perspective on the strategies that medicinal chemists and DMPK scientists now …
Selective Protein Degraders
Tang Group
Researchers in the Tang Group at the University of Wisconsin-Madison, in collaboration with colleagues at NovoNordisk, published in Advanced Science, have engineered an insulin-like …
Helical Peptide Discovery
Suga and Katoh Labs
A team led by Hiroaki Suga and Takayuki Katoh at the University of Tokyo extended their engineered tRNA system, tRNAPro1E2, to incorporate five achiral dαAAs …
Supra-Bivalent Inhibitors
Sengoku and Suga Labs
A collaboration between the laboratories of Professor Hiroaki Suga at the University of Tokyo and Professor Toru Sengoku at Yokohama City University has developed a …
Conditional Miniprotein Activation
Oller-Salvia Lab
Protein therapeutics have transformed treatment of diseases from cancer to immune disorders, yet many targets appear not only at diseased sites but also in healthy …
ACE-Inhibitory Peptides
Beys-da-Silva Lab
Hypertension remains the leading cause of premature death worldwide, yet one in five affected adults achieve adequate blood pressure control. Angiotensin-converting enzyme inhibitors represent one …
Mirror-Image Hunters
Denisov/Dijkgraaf Labs
Chemokines make frustrating drug targets. These small signaling proteins orchestrate immune cell migration during inflammation, making them attractive therapeutic targets for conditions ranging from atherosclerosis …
Modeling Selectivity
Miller Lab
Chiral sulfur compounds are gaining traction in drug discovery. Unlike their achiral counterparts, molecules with stereogenic sulfur centers often show improved potency and selectivity. IFM …
Helical Hijackers
Cai Lab
The Wnt/β-catenin signaling pathway governs embryonic development, stem cell maintenance, and tissue homeostasis. When aberrantly activated, it drives colorectal cancer and other malignancies. Inside the …
Covalent Peptide Libraries
Bode Lab
Covalent inhibitors provide potent and durable target engagement, with approved drugs such as ibrutinib and osimertinib validating the approach. These compounds exploit electrophilic warheads to …
Peptide Aggregation Blockers
Wright Lab
The misfolding and aggregation of transthyretin, TTR, a serum protein responsible for transporting thyroxine and retinol binding protein, underlies a class of amyloid diseases that …
Engineered Lasso Peptides
Burk Lab
A major barrier to durable responses with PD-1/PD-L1 checkpoint inhibitors is the activation of immunosuppressive TGF-β within the tumor microenvironment. This immunosuppression is driven in …
Coagulation Trigger
Ruvo Lab
Hemostasis begins with a handshake. When vascular damage exposes tissue factor, TF, to the bloodstream, factor VII, FVII, latches on, instantly engaging the extrinsic pathway …
Allosteric Turns
Sampaio-Dias Lab
Disorders of the central nervous system linked to dysregulation of dopamine D2 receptors — including depression, drug addiction, Parkinson’s disease, and movement disorders — …
Degrading Light
Lou Lab
Targeted protein degradation has rapidly matured into a transformative drug discovery approach, offering ways to dismantle proteins once deemed undruggable. While classical proteolysis-targeting chimeras, PROTACs, …
Blocking Metastasis
Kennedy Lab
Metastasis remains the leading cause of cancer mortality, and one driver of this process is the actin cytoskeleton remodeling mediated by WASF3, a protein strongly …
Peptide Anti Obesity 2.0
David Lab
Obesity is a leading contributor to global disease burden and a primary risk factor for type 2 diabetes, yet current treatments often lack specificity and …
Conjugation Chemistry
Kwon Lab
Traumatic brain injury, TBI, remains a profound and unresolved clinical challenge, responsible for long-term disability in both civilian and military populations. The lack of effective …