Peptide Publications Archive
NRPS Golden Gate
Bode Lab
A modular Golden Gate–based workflow unites the XUT concept with non-ribosomal peptide synthetase engineering, enabling rapid, scarless assembly of hybrid enzymes. Over 100 constructs yielded …
Mirror-Image Hunters
Denisov/Dijkgraaf Labs
Chemokines make frustrating drug targets. These small signaling proteins orchestrate immune cell migration during inflammation, making them attractive therapeutic targets for conditions ranging from atherosclerosis …
Luminescent Nanosheets
Granja/Montenegro Labs
Two-dimensional materials have captivated researchers since graphene's isolation in 2004, offering properties unmatched by their bulk counterparts. High surface areas, tunable electronics, and morphological anisotropy …
Acoustic Coupling
Lubell Group
The demand for peptide therapeutics is booming, but their manufacture carries a heavy environmental burden. Solid-phase peptide synthesis, SPPS, the workhorse of the field, consumes …
Guided Precision
Waser Lab
Cysteine residues attract chemical attention. Their nucleophilic thiol groups react readily with electrophiles, making them popular handles for attaching drugs, fluorophores, and other payloads to …
Crossing Cell Barriers
Meldal Lab
The cell membrane stands as biology's most formidable gatekeeper. Large molecules, from therapeutic proteins to diagnostic agents, cannot simply walk through. This barrier has frustrated …
Photoclick Bicycles
Lei Lab
Bicyclic peptides offer exceptional promise for targeting protein-protein interactions, combining the conformational rigidity needed for high-affinity binding with improved metabolic stability. Yet their construction remains …
Borrowed Machinery
Xu Lab
N-myristoylation is a common posttranslational modification in which the enzyme N-myristoyltransferase, NMT, attaches a 14-carbon fatty acid to an N-terminal glycine residue. This lipid anchor …
Modeling Selectivity
Miller Lab
Chiral sulfur compounds are gaining traction in drug discovery. Unlike their achiral counterparts, molecules with stereogenic sulfur centers often show improved potency and selectivity. IFM …
Masked Sugars
Dong Lab
Chemical synthesis provides atomic-level control over glycoprotein structure, yet hydrophobic sequences often aggregate before chemists can purify or ligate them. This problem may intensify for …
Helical Hijackers
Cai Lab
The Wnt/β-catenin signaling pathway governs embryonic development, stem cell maintenance, and tissue homeostasis. When aberrantly activated, it drives colorectal cancer and other malignancies. Inside the …
β-Hairpin Oligomers
Nowick Lab
Researchers in the Nowick Group at the University of California Irvine, reveal how a designed β-hairpin peptide derived from amyloid-β, Aβ, crosses the boundary from …
Gelatinase Targeting
Amitava Lab
Antibiotic resistance in Staphylococcus aureus thrives on biofilm fortifications and membrane resilience, which blunt broad-spectrum drugs and damage commensal flora. A modular short peptide, Py-FGGK, …
Optimizing Peptide Switches
Maly Lab
Chemically-controlled genetic tools allow researchers to switch cellular processes on or off with small molecules, offering precise temporal and dose-dependent control. While chemically-inducible dimerization systems …
Taming Arginine
Raj Lab
Selective modification of amino acid side chains has become a central strategy for expanding peptide function beyond the limits of ribosomal chemistry. Yet one residue …
TCR Peptide Design
Nourmohammad Lab
In work published in PNAS, Visani and colleagues from the University of Washington, introduce a structure-aware machine learning approach that forecasts TCR–peptide–MHC interactions and …
Iodo Quantification
Lilienkampf Lab
In work published in ACS Chemical Biology, David J. Clarke, Annamaria Lilienkampf, and collaborators from the University of Edinburgh, introduce an iodo based labeling strategy …
Docking Bias
Keating Lab
Deep-learning structure predictors now place many peptides correctly onto their protein partners, and this recent work from Lindsey Guan and Amy Keating at the Massachusetts …
Dilp Divergence
Bland Lab
Insulin-like peptides orchestrate how animals apportion nutrients between storage and growth, yet distinct ligands may encode different cues even when signaling through a single receptor. …
Sequence Hydrophobicity
Perry Lab
In this study, published in Biomacromolecules, researchers in Sarah Perry's group at the University of Massachusetts - Amherst, employ sequence-defined polypeptides as minimal models …
Affinity Landscapes
Bussemaker Lab
A collaborative study from the Bussemaker and Shah Groups at Columbia University, published in Protein Science, establishes an integrated experimental–computational framework, built on massively …
Alkyne Grasp
Fujishiro Lab
ATP-grasp ligases offer a powerful route to diversify peptide structures, and BesA stands out for its ability to incorporate terminal alkyne groups into dipeptides with …
Aquaporin Bridge
Wang Lab
Researchers from the Wang Group at the School of Life Sciences, Shandong University, China, report in PNAS a mechanistic bridge between two pillars of arthropod …
Peptide Portals
Otto Lab
For decades, antimicrobial peptides, AMPs, have stood at the crossroads between innate immunity and drug discovery, yet their molecular diversity remains incompletely explored. Dickey, Otto, …