Peptide Publications Archive
Glycan–Metal Synergy
Koksch Lab
Hydrogels, highly hydrated polymer networks, underpin both natural barriers such as mucus and numerous biomedical applications. Mucins, the glycoprotein constituents of mucus, achieve their viscoelasticity …
Phosphine Rebridging
Hackenberger Lab
Published in Angewandte Chemie International Editition, researchers from the Hackenberger Lab at the Humboldt-Universität in Berlin, present a powerful new class of phosphine oxide–based …
Helical Hydrazides
Gellman Lab
Seeking to understand the relative kinetic benefits of reactive unit connection and preorganization, researchers from the Gellman Lab at the University of Wisconsin–Madison investigated α/β-peptide …
Serine Switch
Diao Lab
Published in the Journal of the American Chemical Society, work by first author Zhenyan Guo in the Diao Lab at the New York University, …
Ephemeral Pores
Pastor Lab
In a PNAS study, researchers from the Pastor group at the National Institutes of Health, NIH, and the Cotten group at Oregon State University present …
Copper Clicks
Metanis Lab
In a collaborative work between the Metanis and Shimon labs at the Hebrew University of Jerusalem, and the Wang group at the Xiamen University in …
Mitochondrial Click
Wennemers Lab
In work published in ACS Chemical Biology, Adeline Schmitt, under the guidance of Helma Wennemers at ETH Zürich, investigated rigid polyproline II, PPII, helical …
Covalent Peptide Libraries
Bode Lab
Covalent inhibitors provide potent and durable target engagement, with approved drugs such as ibrutinib and osimertinib validating the approach. These compounds exploit electrophilic warheads to …
Lanthipeptide Modeling
Walker Lab
Lanthipeptides, the thioether-crosslinked members of the RiPP family, are compelling antibiotic scaffolds. Yet, they have remained largely outside the reach of structure-based design. Standard modeling …
Photoregulated Catalysis
Bandyopadhyay Lab
Precise external regulation of enzymatic activity remains a central goal in chemical biology, with wide-ranging implications for biotechnology, diagnostics, and medicine. Natural proteases govern countless …
Peptide Aggregation Blockers
Wright Lab
The misfolding and aggregation of transthyretin, TTR, a serum protein responsible for transporting thyroxine and retinol binding protein, underlies a class of amyloid diseases that …
Engineered Lasso Peptides
Burk Lab
A major barrier to durable responses with PD-1/PD-L1 checkpoint inhibitors is the activation of immunosuppressive TGF-β within the tumor microenvironment. This immunosuppression is driven in …
Spike Peptide Amyloids
Legleiter Lab
SARS-CoV-2 spike protein fragments are known to form amyloid fibrils, but far less is understood about the prefibrillar states that emerge along the way, or …
HDAC-Mediated Lactylation
Goldberg Lab
Lysine lactylation, Kla, has emerged as a post-translational modification, PTM, directly linking glycolytic metabolism to protein regulation. While earlier models invoked lactyl-CoA–dependent transfer or non-enzymatic …
Targeted Conjugates
Zeglis Lab
For two decades, immunoconjugates have been a mainstay of targeted oncology, from antibody–drug conjugates to radioimmunotherapy probes. The clinical challenge has never been the underlying …
Ultrafast Peptide Cyclization
Sun Lab
Cyclic peptides occupy a privileged niche in chemical biology. Their constrained conformations reduce entropic penalties upon binding, impart proteolytic stability, and frequently enable access to …
Cysteine Umpolung
Wang Lab
A longstanding challenge in peptide chemistry has been the restricted reactivity of canonical amino acids, which limits late-stage functionalization strategies. Most side chains are inherently …
Azapeptoid Collagen
Del Valle Lab
Collagen’s mechanical grace comes from a deceptively simple code: repeating Gly-Xaa-Yaa triplets that assemble into three left-handed PPII chains winding into a right-handed triple helix. …
Coagulation Trigger
Ruvo Lab
Hemostasis begins with a handshake. When vascular damage exposes tissue factor, TF, to the bloodstream, factor VII, FVII, latches on, instantly engaging the extrinsic pathway …
Rewiring the Protein Backbone
Schepartz Lab
Backbone editing offers a powerful way to expand protein function: by introducing β, γ, or δ linkages, researchers can strengthen folds against proteolysis, reshape ligand …
Allosteric Turns
Sampaio-Dias Lab
Disorders of the central nervous system linked to dysregulation of dopamine D2 receptors — including depression, drug addiction, Parkinson’s disease, and movement disorders — …
Stapled Sheets
Del Valle Lab
The stabilization of β-sheet structures has long been a challenge in peptide design, despite their central role in mediating protein–protein interactions, PPIs. While side-chain …
Degrading Light
Lou Lab
Targeted protein degradation has rapidly matured into a transformative drug discovery approach, offering ways to dismantle proteins once deemed undruggable. While classical proteolysis-targeting chimeras, PROTACs, …
Blocking Metastasis
Kennedy Lab
Metastasis remains the leading cause of cancer mortality, and one driver of this process is the actin cytoskeleton remodeling mediated by WASF3, a protein strongly …