Peptide Publications Archive
Programmable Peptide Coacervates
Tian Lab
Peptide-based coacervates have emerged as versatile platforms for drug delivery, tissue scaffolding, bioreactor systems, and cellular regulation due to their sequence programmability, dynamic self-assembly, and …
Conditional Miniprotein Activation
Oller-Salvia Lab
Protein therapeutics have transformed treatment of diseases from cancer to immune disorders, yet many targets appear not only at diseased sites but also in healthy …
Chiral Prodrug Synthesis
Kong Lab
Carboxylic acid groups frequently serve as essential pharmacophores in drug molecules, yet their high polarity limits membrane permeability and can reduce bioavailability. Prodrug strategies address …
Computational Peptide Design
Guo Group
Xanthine oxidase catalyzes the final steps of purine catabolism, converting hypoxanthine and xanthine to uric acid. Dysregulation of this enzyme leads to excessive uric acid …
ACE-Inhibitory Peptides
Beys-da-Silva Lab
Hypertension remains the leading cause of premature death worldwide, yet one in five affected adults achieve adequate blood pressure control. Angiotensin-converting enzyme inhibitors represent one …
Nitrogen Walks
Huang/Xiao Labs
Noncanonical amino acids have become indispensable tools in chemical biology and drug discovery. By introducing side chains that nature never encoded, researchers can endow peptides …
Beyond Alpha
Ohshima/Yazaki Labs
Unnatural amino acids have transformed both medicinal chemistry and chemical biology. By introducing side chains that nature never encoded, chemists can enhance metabolic stability, tune …
Clicking Safely
Jain Lab
The 1,2,3-triazole ring has become indispensable in peptidomimetic design. Its geometry and electronic properties closely mimic the trans-amide bond: similar planarity, comparable dipole moment, and …
Catching Lanthanides
Zeymer Lab
Lanthanide ions offer an extraordinary toolkit for biomolecular engineering. Their long-lived luminescence enables sensitive detection, their paramagnetism provides NMR structural probes, their strong anomalous X-ray …
Designing Droplets
Pina Lab
Cells organize their interiors not only with membranes but also through liquid-liquid phase separation, LLPS, the spontaneous demixing that creates membraneless organelles like nucleoli and …
Binders by Design
Pomplun Lab
Discovering high-affinity ligands directly from protein structures has long tantalized drug discovery scientists. Virtual screening can explore billions of small molecules computationally, yet hit rates …
Ribosomal Bicycles
Suga Lab
Bicyclic peptides occupy a sweet spot in drug discovery. Their constrained architectures resist proteolytic degradation and bind targets with antibody-like specificity, yet they remain small …
Taming Aggregation
Hartrampf Lab
Peptide chains misbehave. During solid-phase peptide synthesis, growing chains can collapse into sticky β-sheet structures that clog the resin, block coupling reactions, and leave chemists …
NRPS Golden Gate
Bode Lab
A modular Golden Gate–based workflow unites the XUT concept with non-ribosomal peptide synthetase engineering, enabling rapid, scarless assembly of hybrid enzymes. Over 100 constructs yielded …
Mirror-Image Hunters
Denisov/Dijkgraaf Labs
Chemokines make frustrating drug targets. These small signaling proteins orchestrate immune cell migration during inflammation, making them attractive therapeutic targets for conditions ranging from atherosclerosis …
Luminescent Nanosheets
Granja/Montenegro Labs
Two-dimensional materials have captivated researchers since graphene's isolation in 2004, offering properties unmatched by their bulk counterparts. High surface areas, tunable electronics, and morphological anisotropy …
Acoustic Coupling
Lubell Group
The demand for peptide therapeutics is booming, but their manufacture carries a heavy environmental burden. Solid-phase peptide synthesis, SPPS, the workhorse of the field, consumes …
Guided Precision
Waser Lab
Cysteine residues attract chemical attention. Their nucleophilic thiol groups react readily with electrophiles, making them popular handles for attaching drugs, fluorophores, and other payloads to …
Crossing Cell Barriers
Meldal Lab
The cell membrane stands as biology's most formidable gatekeeper. Large molecules, from therapeutic proteins to diagnostic agents, cannot simply walk through. This barrier has frustrated …
Photoclick Bicycles
Lei Lab
Bicyclic peptides offer exceptional promise for targeting protein-protein interactions, combining the conformational rigidity needed for high-affinity binding with improved metabolic stability. Yet their construction remains …
Borrowed Machinery
Xu Lab
N-myristoylation is a common posttranslational modification in which the enzyme N-myristoyltransferase, NMT, attaches a 14-carbon fatty acid to an N-terminal glycine residue. This lipid anchor …
Modeling Selectivity
Miller Lab
Chiral sulfur compounds are gaining traction in drug discovery. Unlike their achiral counterparts, molecules with stereogenic sulfur centers often show improved potency and selectivity. IFM …
Masked Sugars
Dong Lab
Chemical synthesis provides atomic-level control over glycoprotein structure, yet hydrophobic sequences often aggregate before chemists can purify or ligate them. This problem may intensify for …
Helical Hijackers
Cai Lab
The Wnt/β-catenin signaling pathway governs embryonic development, stem cell maintenance, and tissue homeostasis. When aberrantly activated, it drives colorectal cancer and other malignancies. Inside the …