Peptide Publications Archive
Dynamic Ion Channels
Niitsu Lab
Membrane-spanning peptides that form ion-conductive channels remain a challenging frontier in de novo protein design. While strides have been made in creating water-soluble peptide assemblies, …
Antimicrobial Peptide
D'Amelio Lab
As antibiotic resistance surges worldwide, the search for effective new therapeutics has led scientists to a surprising source: the venom of Bungarus fasciatus, the …
Protein Design
Tezcan Lab
Isopeptide bonds, IPBs, — covalent linkages between the side chains of lysine and asparagine/glutamine or aspartate/glutamate — are remarkable for their chemical resilience and structural …
Enlicitide Decanoate
Thaisrivongs Lab
The total synthesis and process development of enlicitide decanoate, MK-0616, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9, PCSK9, represents a major breakthrough …
Arginine Carbonylation
Raj Lab
The selective incorporation of post-translational modifications, PTMs, into proteins remains a key challenge in chemical biology, particularly for modifications like arginine carbonylation, which plays a …
Vesicle Inversion
Deming Lab
Self-assembled polymeric vesicles that respond to biologically relevant stimuli have significant potential in drug delivery and synthetic biology. While many stimuli-responsive assemblies disassemble upon activation, …
Electrophilic Warheads
Research Lab
Understanding how proteins interact with biological metabolites is crucial for deciphering biological processes and advancing therapeutic strategies. This study focuses on a specific class of …
Selective Coupling
Suga Lab
α,β-Dehydroalanine, ΔAla, is a highly reactive nonproteinogenic amino acid that serves as a versatile handle for modifying peptides, natural products, NPs, and proteins. While many …
Vancomycin–Teixobactin
Nowick Lab
Vancomycin, a cornerstone antibiotic for Gram-positive infections, faces diminishing efficacy due to the emergence of vancomycin-resistant Enterococci, VRE, and vancomycin-resistant...
Synthesis Tag
Hartrampf Lab
Solid-phase peptide synthesis, SPPS, and native chemical ligation, NCL, are powerful methods for obtaining peptides and proteins that are otherwise inaccessible...
Peptide Modifications
Phan Lab
Ribosomally synthesized and post-translationally modified peptides, RiPPs, represent an expanding class of natural products distinguished by their extensive post-translational modifications. Among the enzymatic systems...
Genome Mining
Agarwal Lab
Brominated intermediates have long been favored in organic synthesis for their chemical versatility, particularly in transition-metal-assisted bond-forming reactions. The Agarwal and van der Donk study …
Backbone Editing
Schepartz Lab
The ability to precisely manipulate the peptide backbone remains one of the fundamental challenges in biomolecular engineering. While ribosomal translation and peptide synthesis methods allow …
Super-Res Microscopy
Guha Lab
Researchers in the Samit Guha Group at Jadavpur University, Kolkata, India, published in Bioconjugate Chemistry, report a groundbreaking approach to cancer imaging...
Selective Cyclization
Liu Lab
To address the limitations of current methods for peptide macrocyclization, which often rely on nonspecific small-molecule linkers...
Molecular Flasks
Woolfson Lab
To address the formidable challenge of binding and orienting multiple small molecules for directed chemical reactions, researchers in the Woolfson and Oliver groups at the …
Yeast CICLOPPS
Knudsen Lab
Researchers in the Knudsen Group at the University of Aarhus, Denmark, published in Biochemistry, report the construction of a Saccharomyces cerevisiae-specific SICLOPPS library …
Graspetides
Ding Lab
Published in ACS Chemical Biology, researchers in the Ding Group at the University of Florida, reconstructed prunipeptin biosynthesis from Streptomyces coelicolor...
Metallo-Azapeptides
Proulx Lab
Published in the Journal of the American Chemical Society, researchers in the Proulx group at the North Carolina State University at Raleigh, present the …