Peptide Publications Archive
Ribosomal Bicycles
Suga Lab
Bicyclic peptides occupy a sweet spot in drug discovery. Their constrained architectures resist proteolytic degradation and bind targets with antibody-like specificity, yet they remain small …
Taming Aggregation
Hartrampf Lab
Peptide chains misbehave. During solid-phase peptide synthesis, growing chains can collapse into sticky β-sheet structures that clog the resin, block coupling reactions, and leave chemists …
NRPS Golden Gate
Bode Lab
A modular Golden Gate–based workflow unites the XUT concept with non-ribosomal peptide synthetase engineering, enabling rapid, scarless assembly of hybrid enzymes. Over 100 constructs yielded …
Mirror-Image Hunters
Denisov/Dijkgraaf Labs
Chemokines make frustrating drug targets. These small signaling proteins orchestrate immune cell migration during inflammation, making them attractive therapeutic targets for conditions ranging from atherosclerosis …
Luminescent Nanosheets
Granja/Montenegro Labs
Two-dimensional materials have captivated researchers since graphene's isolation in 2004, offering properties unmatched by their bulk counterparts. High surface areas, tunable electronics, and morphological anisotropy …
Acoustic Coupling
Lubell Group
The demand for peptide therapeutics is booming, but their manufacture carries a heavy environmental burden. Solid-phase peptide synthesis, SPPS, the workhorse of the field, consumes …
Guided Precision
Waser Lab
Cysteine residues attract chemical attention. Their nucleophilic thiol groups react readily with electrophiles, making them popular handles for attaching drugs, fluorophores, and other payloads to …
Crossing Cell Barriers
Meldal Lab
The cell membrane stands as biology's most formidable gatekeeper. Large molecules, from therapeutic proteins to diagnostic agents, cannot simply walk through. This barrier has frustrated …
Photoclick Bicycles
Lei Lab
Bicyclic peptides offer exceptional promise for targeting protein-protein interactions, combining the conformational rigidity needed for high-affinity binding with improved metabolic stability. Yet their construction remains …
Borrowed Machinery
Xu Lab
N-myristoylation is a common posttranslational modification in which the enzyme N-myristoyltransferase, NMT, attaches a 14-carbon fatty acid to an N-terminal glycine residue. This lipid anchor …
Modeling Selectivity
Miller Lab
Chiral sulfur compounds are gaining traction in drug discovery. Unlike their achiral counterparts, molecules with stereogenic sulfur centers often show improved potency and selectivity. IFM …
Masked Sugars
Dong Lab
Chemical synthesis provides atomic-level control over glycoprotein structure, yet hydrophobic sequences often aggregate before chemists can purify or ligate them. This problem may intensify for …