Peptide Publications Archive
Peptide Aggregation Blockers
Wright Lab
The misfolding and aggregation of transthyretin, TTR, a serum protein responsible for transporting thyroxine and retinol binding protein, underlies a class of amyloid diseases that …
Engineered Lasso Peptides
Burk Lab
A major barrier to durable responses with PD-1/PD-L1 checkpoint inhibitors is the activation of immunosuppressive TGF-β within the tumor microenvironment. This immunosuppression is driven in …
Spike Peptide Amyloids
Legleiter Lab
SARS-CoV-2 spike protein fragments are known to form amyloid fibrils, but far less is understood about the prefibrillar states that emerge along the way, or …
HDAC-Mediated Lactylation
Goldberg Lab
Lysine lactylation, Kla, has emerged as a post-translational modification, PTM, directly linking glycolytic metabolism to protein regulation. While earlier models invoked lactyl-CoA–dependent transfer or non-enzymatic …
Targeted Conjugates
Zeglis Lab
For two decades, immunoconjugates have been a mainstay of targeted oncology, from antibody–drug conjugates to radioimmunotherapy probes. The clinical challenge has never been the underlying …
Ultrafast Peptide Cyclization
Sun Lab
Cyclic peptides occupy a privileged niche in chemical biology. Their constrained conformations reduce entropic penalties upon binding, impart proteolytic stability, and frequently enable access to …
Cysteine Umpolung
Wang Lab
A longstanding challenge in peptide chemistry has been the restricted reactivity of canonical amino acids, which limits late-stage functionalization strategies. Most side chains are inherently …
Azapeptoid Collagen
Del Valle Lab
Collagen’s mechanical grace comes from a deceptively simple code: repeating Gly-Xaa-Yaa triplets that assemble into three left-handed PPII chains winding into a right-handed triple helix. …
Coagulation Trigger
Ruvo Lab
Hemostasis begins with a handshake. When vascular damage exposes tissue factor, TF, to the bloodstream, factor VII, FVII, latches on, instantly engaging the extrinsic pathway …
Rewiring the Protein Backbone
Schepartz Lab
Backbone editing offers a powerful way to expand protein function: by introducing β, γ, or δ linkages, researchers can strengthen folds against proteolysis, reshape ligand …
Allosteric Turns
Sampaio-Dias Lab
Disorders of the central nervous system linked to dysregulation of dopamine D2 receptors — including depression, drug addiction, Parkinson’s disease, and movement disorders — …
Stapled Sheets
Del Valle Lab
The stabilization of β-sheet structures has long been a challenge in peptide design, despite their central role in mediating protein–protein interactions, PPIs. While side-chain …