Peptide Publications Archive
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Rewiring the Protein Backbone
Schepartz Lab
Backbone editing offers a powerful way to expand protein function: by introducing β, γ, or δ linkages, researchers can strengthen folds against proteolysis, reshape ligand …
Oxidative Peptide Coupling
Proulx Lab
This study demonstrates that a key determinant of this reactivity is the choice of solvent. By shifting from aqueous buffer to a mixed organic solvent …
Versatile Precursors
Mitchell Lab
Cyclopropane-containing amino acids, prized for their conformational rigidity and stability, are of increasing interest in therapeutic peptide development and antimicrobial drug discovery. A recent study …
Selective Coupling
Suga Lab
α,β-Dehydroalanine, ΔAla, is a highly reactive nonproteinogenic amino acid that serves as a versatile handle for modifying peptides, natural products, NPs, and proteins. While many …
Synthesis Tag
Hartrampf Lab
Solid-phase peptide synthesis, SPPS, and native chemical ligation, NCL, are powerful methods for obtaining peptides and proteins that are otherwise inaccessible...
Backbone Editing
Schepartz Lab
The ability to precisely manipulate the peptide backbone remains one of the fundamental challenges in biomolecular engineering. While ribosomal translation and peptide synthesis methods allow …
Metallo-Azapeptides
Proulx Lab
Published in the Journal of the American Chemical Society, researchers in the Proulx group at the North Carolina State University at Raleigh, present the …