Peptide Publications Archive
Showing items in Peptide Design · Clear filter
Grafted Coiled Coils
Andrew J. Lab
Protein–protein interactions, PPIs, are fundamental to cellular regulation, yet targeting them therapeutically remains challenging due to their extensive, shallow interfaces. Peptides offer an attractive solution, …
Sequence Architecture
Woolfson Lab
The Woolfson Lab continues to break new ground in de novo protein design with the successful creation of mixed-charge A3B3 heterohexameric α-helical …
Dynamic Ion Channels
Niitsu Lab
Membrane-spanning peptides that form ion-conductive channels remain a challenging frontier in de novo protein design. While strides have been made in creating water-soluble peptide assemblies, …
Protein Design
Tezcan Lab
Isopeptide bonds, IPBs, — covalent linkages between the side chains of lysine and asparagine/glutamine or aspartate/glutamate — are remarkable for their chemical resilience and structural …
Molecular Flasks
Woolfson Lab
To address the formidable challenge of binding and orienting multiple small molecules for directed chemical reactions, researchers in the Woolfson and Oliver groups at the …