Yvonne M. Angell

Yvonne M. Angell

Yvonne M. Angell
Councilor
Director of Peptide Chemistry
ChemPartner

Professional Positions

ChemPartner, Director of Peptide Chemistry, 2015-Present
Ipsen Bioscience, Inc., Director of Peptide and Protein Chemistry, 2010-2015
Picotide Technologies, Founder and Principal, 2008-2010
Affymax, Inc., Senior Scientist, 2007-2008
Affymax, Inc., Staff Scientist II, 2003-2007
Wyeth Pharmaceuticals, Staff Scientist II, 2001-2003
Sphinx Pharmaceuticals, division of Eli Lilly & Co., Staff Scientist, 1998-2001

Education

Ph.D., Medicinal Chemistry, University of Wisconsin, Madison, 1996
Bachelor of Science in Pharmacy, University of Wisconsin, Madison, 1990,

APS Service

Member, Nominating Committee, 2017-2019

Awards & Honors

Vice President, Boulder Peptide Society, 2016 - present
Board of Directors, Peptide Therapeutics Foundation, 2014 - 2015

Research Interest

My research interests include discovery and implementation of new approaches for synthesis of challenging peptides and proteins and novel approaches for peptide stabilization and formulation.

Personal Statement

For many years, my career has been focused on the discovery and development of new chemical entities in various therapeutic areas (oncology, endocrinology, hematology and neurology) for treatment of diseases with unmet medical need. I have built a strong reputation in the peptide therapeutics field by leading successful chemistry teams and research programs in small biotech companies, mid-size and large pharmaceutical companies. My main expertise is in the synthesis and optimization of challenging peptides and peptidomimetics, conjugate linker design and synthesis, unnatural amino acid and building block synthesis, peptide PEGylation and lipidation, formulation and CMC activities. I have influenced the strategic direction to advance many drug discovery programs including three drug candidates in preclinical development, one in the market, and one in phase I clinical trials.

I have participated in every APS meeting since 1991, and it would be an honor to serve on the APS Nominating Committee. I see this as a great way to network with colleagues and give back to the broader community of researchers interested in peptide chemistry. I organized the quarterly Cambridge PEPtalks scientific seminar series from 2013 - 2015, and now organize the Bay Area PEPtalks meetings to bring together local area scientists interested in peptide and protein science for scientific discussions, idea sharing and networking. This is another way in which I give back to the broader peptide research community.

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Proteins in Hours

Proteins in Hours

Advancements in the field of biopharmaceuticals and protein engineering necessitate the development of new methods for on-demand production of chemically modified proteins and peptides. Standard solid-phase...