Peptide Science at the Summit

APS Symposium | June 12-17, 2021 | Whistler, BC

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News Archive

Research and News Archive

Fluorescent Peptide

Fluorescent Peptide

Teixobactin is a nonribosomal antibiotic peptide that inhibits the biosynthesis of peptidoglycan and teichoic acid, however, teixobactin’s cellular site of action is unknown...

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Constrained Peptides

Constrained Peptides

Guéret and colleagues describe a versatile method for inserting chiral motifs between the ends of omega loops. Peptides are synthesized using traditional SPPS...

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Coupling Agent Hazards

Coupling Agent Hazards

This case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, is a cautionary note for researchers who handle peptide coupling agents frequently...

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Molecular Transporters

Molecular Transporters

In this collaborative study, researchers have designed a new generation of peptides based on previously designed cyclic cell-penetrating peptides. They have evaluated their cytotoxicity as well as uptake behavior...

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C1B1 Inhibition

C1B1 Inhibition

In this recent publication, Puhl et al. have employed random peptide phage display to screen and select peptides that bind to the calcium and integrin binding protein 1 (CIB1)...

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Aqueous SPPS

Aqueous SPPS

The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly...

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Cyclotide Uptake

Cyclotide Uptake

In this study, the recently developed chloroalkane penetration assay was combined with established assays to characterize the cellular uptake and cytosolic delivery of the prototypic cyclotide, kalata B1...

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Peptide Synthesis

Peptide Synthesis

In this recent Science publication, Hartrampf et al. report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing of peptide chains up to 164 amino acids long...

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Cyclotide Production

Cyclotide Production

In this manuscript researchers in Dr. Craik's lab describe a strategy to improve the production of cyclotides, which are usually produced and cyclized synthetically at a high cost and environmental impact for large scale.

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Improved Thiol Protection

Improved Thiol Protection

Photoremovable caging groups are useful for biological applications because the deprotection process can be initiated by illumination with light without the necessity of adding additional reagents...

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Peptide Self Assembly

Peptide Self Assembly

Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes...

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Peptide Mimics

Peptide Mimics

Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications...

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γ-Amino Acids Elongation

γ-Amino Acids Elongation

Because γ-amino acids generally undergo rapid self-cyclization upon esterification on the carboxyl group, for example, γ-aminoacyl-tRNA, there are no reports of the ribosomal elongation...

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Nanosheet Fabrication

Nanosheet Fabrication

Engineering free-standing 2D nanomaterials with compositional, spatial, and functional control across size regimes from the nano- to mesoscale represents a significant challenge....

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Hydrophobic Moieties

Hydrophobic Moieties

Trans amide bonds and fast cis–trans isomerization of Xaa-Pro bonds are crucial for the stability and folding rate of collagen, the most abundant protein in mammals...

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Platinum Nanoparticles

Platinum Nanoparticles

Hepatocellular carcinoma, HCC, is the sixth most frequent cancer and the second leading cause of death from cancer worldwide. Sorafenib is the most commonly used FDA‐approved systemic...

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Ice Nucleators

Ice Nucleators

In a manuscript published in Langmuir, Yuki Kamijo and Ratmir Derda from the, University of Alberta, describe a screening system that employs the difference...

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Ghost Peptides

Ghost Peptides

A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Published in ACS Chemical Biology, and presented...

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Octreotide Analogs

Octreotide Analogs

Somatostatin, SS, is a cyclic tetradecapeptide able to inhibit the release of growth hormone, GH, mainly through the binding to two G‐protein coupled...

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Enzyme Sequestration

Enzyme Sequestration

Liquid-like droplets of biomacromolecules are emerging as a fundamental mechanism of cellular signaling, but designing synthetic mimics to form such...

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Short Peptides

Short Peptides

Helical secondary and tertiary motifs are commonly observed as binding epitopes in natural and engineered protein scaffolds. While several strategies...

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Roads to Rome

Roads to Rome

Ribosomally synthesized and post-translationally modified peptides, RiPPs, are ubiquitous natural products. Bioactive RiPPs are produced from a precursor...

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Azapeptide Libraries

Azapeptide Libraries

Aza‐propargylglycine, azaPra, peptides are branching points for the synthesis of azapeptide libraries. Researchers in the Lubell Lab, published in...

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Unprotected Peptides

Unprotected Peptides

Ring-closing metathesis, RCM, is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected...

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Young Investigator

Young Investigator

Buyan Pan is one of the winners of the Peptide Science Poster Awards at the 2019 American Peptide Symposium in Monterey, CA...

New APS Members

New APS Members

We extend a warm welcome to those who recently joined our Society: Deguo Du, Reyhaneh Shams Khozani, Sarmistha Saha, Michael, Taylor, and Paula Giraldo.