Research and News Archive

B-cell Epitope

B-cell Epitope

Herein, researchers in the Kaumaya lab describe a novel PD-1 B-cell peptide epitope vaccine (amino acid 92–110; PD1-Vaxx) linked to a measles virus fusion peptide...

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Peptide Cancer Vaccines

Peptide Cancer Vaccines

In this article, Professor Pravin Kaumaya reviews his lab's approaches and strategies that focus on B-cell epitope cancer vaccines...

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Production Technology

Production Technology

The production of peptides as active pharmaceutical ingredients (APIs) by recombinant technologies is of emerging interest. A reliable production platform, however...

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Protein Synthesis

Protein Synthesis

Chemical protein synthesis is a powerful avenue for accessing homogeneously modified proteins, but access to large targets has proved challenging...

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Peptide Libraries

Peptide Libraries

Herein is described a divergent late-stage approach to generating macrocyclic peptide libraries with unnatural pharmacophores from readily available starting material...

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Peptide Synthesis

Peptide Synthesis

Despite six decades of efforts to synthesize peptides and proteins bearing multiple disulfide bonds, this synthetic challenge remains an unsolved problem...

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Peptide-Based Vaccines

Peptide-Based Vaccines

In this Review, the authors discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer’s disease, and cancer...

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Stapled Peptides

Stapled Peptides

Diabetes is characterized by pancreas dysfunction and is commonly associated with obesity. Hypoglycemic agents capable of improving β-cell function...

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Protein-Protein Interactions

Protein-Protein Interactions

Herein is reported the first application of protein-observed fluorine (PrOF) NMR to the tandem bromodomains of BRD4 and BRDT to quantify the selectivity of their...

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Lariat Peptides

Lariat Peptides

Many lariat peptide natural products exhibit interesting biological activities, and some, such as griselimycin and didemnin B, are membrane permeable...

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Endosomal Escape

Endosomal Escape

Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies for endosomal cargo release...

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Oxime Ligation

Oxime Ligation

The current review will focus on the authors’ use of peptide ligation to optimize PPI antagonists directed against several targets...

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Tyr-Lock Peptide

Tyr-Lock Peptide

High-throughput screening for inhibitors of TDP1 activity resulted in the discovery of a new class of knotted cyclic peptides...

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DNA nanotechnology

DNA nanotechnology

DNA nanotechnology is an emerging field that promises fascinating opportunities for the manipulation and imaging of proteins on a cell surface...

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Cyclic Peptide Ligands

Cyclic Peptide Ligands

Herein is identified three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation−mRNA display selection platform...

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Peptidomimetic Uptake

Peptidomimetic Uptake

Researchers in the Arora Lab observed that the cellular uptake of peptides is critically determined by the cell line-specifically, they noted that peptides show better uptake...

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Antimicrobial Synergy

Antimicrobial Synergy

Authors Chelcie Eller and Ron Raines find that human LL-37 and human RNase 1 can act synergistically to kill Gram-negative bacterial cells...

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Social Media Guide

Social Media Guide

An ACS editorial that provides scientists a guide to navigating and using social media to share ideas and enhance connections...

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Membrane-Lytic Peptides

Membrane-Lytic Peptides

Herein is described the use of peptide backbone N-methylation as a new strategy to transform membrane-lytic peptides (MLPs) into cytocompatible intracellular delivery vehicles...

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Frog-skin Peptides

Frog-skin Peptides

In this study, the researchers investigated naturally occurring peptides derived from frog skin secretions for selectivity and activity toward melanocortin receptors...

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Flow SPPS

Flow SPPS

Flow‐based approaches to solid phase peptide synthesis (SPPS) have been pursued since the method's early days, with anticipated gains in...

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Bioorthogonal Conjugation

Bioorthogonal Conjugation

This minireview intends provides an up‐to‐date overview on the various bioorthogonal strategies implemented for the conjugation of transition organometallic entities...

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Coronavirus Inhibitors

Coronavirus Inhibitors

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1...

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Anti-infective Peptoids

Anti-infective Peptoids

This feature article highlights the progress that has been made towards the development of novel anti-infective peptoids...

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Targeting Malaria

Targeting Malaria

Herein is a review of ongoing research aimed at developing constrained peptides targeting protein-protein interactions pertinent to malaria pathogenesis.

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Disrupt Ubiquitination

Disrupt Ubiquitination

The ubiquitin–proteasome system (UPS) is a highly regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be an effective cancer treatment.

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Cell Permeability

Cell Permeability

In a larger collaborative effort, these researchers have combined the strategies to identify the first examples of all-D α-helical stapled and stitched peptides.

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Peptide Hydrogels

Peptide Hydrogels

Herein, a noninteracting multiphase molecular assembly approach is developed to crystallize tofacitinib, a potent JAK1/3 inhibitor, within a shearthinning self-assembled fibrillar peptide hydrogel network...

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Antimicrobial Peptides

Antimicrobial Peptides

Church et al. report a tunable chemical genetics approach for enhancing genetic code expansion in different wild-type bacterial strains..

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Protein Stability

Protein Stability

Abundant n → π* interactions between adjacent backbone carbonyl groups are predicted to play an important role in dictating the structure of proteins...

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Modified Amino Acids

Modified Amino Acids

Herein, Wang et al. present a photoredox-catalyzed asymmetric method for the preparation of enantiopure β-thiolated/selenolated amino acids using a simple chiral auxiliary...

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Mapping SARS-CoV-2

Mapping SARS-CoV-2

Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of diagnostic tools...

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COVID-19 Therapeutics

COVID-19 Therapeutics

In this review, the researchers summarize peptide and peptide based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...

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Stapled Peptides

Stapled Peptides

This colloborative work between the Garner and Kritzer labs shows their continued efforts to develop and characterization of a cell-penetrant lactam stapled peptide for targeting cellular eIF4E...

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Tyrosine Sulfation

Tyrosine Sulfation

Researchers at the University of Sydney have shown that the evasin protein ACA-01 from the Amblyomma cajennense tick can be posttranslationally sulfated at two tyrosine residues...

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Micelle-assisted Reactions

Micelle-assisted Reactions

This publication shows that micelle-assisted reaction can facilitate native chemical ligations between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety...

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Chemical Protein Synthesis

Chemical Protein Synthesis

Herein is reported an operationally simple method to facilitate chemical protein synthesis by fully convergent and one-pot native chemical ligations...

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Targeting GPCRs

Targeting GPCRs

This recently published review discusses the current status of the peptide drugs targeting G protein-coupled receptors (GPCRs), with a focus on evolving strategies...

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β-Turn Mimics

β-Turn Mimics

Researchers report a simple reductive amination protocol to ligate two peptides, while simultaneously installing a β-turn mimic at the ligation junction...

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Fluorescent Peptide

Fluorescent Peptide

Teixobactin is a nonribosomal antibiotic peptide that inhibits the biosynthesis of peptidoglycan and teichoic acid, however, teixobactin’s cellular site of action is unknown...

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Constrained Peptides

Constrained Peptides

Guéret and colleagues describe a versatile method for inserting chiral motifs between the ends of omega loops. Peptides are synthesized using traditional SPPS...

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Coupling Agent Hazards

Coupling Agent Hazards

This case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, is a cautionary note for researchers who handle peptide coupling agents frequently...

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Molecular Transporters

Molecular Transporters

In this collaborative study, researchers have designed a new generation of peptides based on previously designed cyclic cell-penetrating peptides. They have evaluated their cytotoxicity as well as uptake behavior...

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C1B1 Inhibition

C1B1 Inhibition

In this recent publication, Puhl et al. have employed random peptide phage display to screen and select peptides that bind to the calcium and integrin binding protein 1 (CIB1)...

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Aqueous SPPS

Aqueous SPPS

The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly...

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Cyclotide Uptake

Cyclotide Uptake

In this study, the recently developed chloroalkane penetration assay was combined with established assays to characterize the cellular uptake and cytosolic delivery of the prototypic cyclotide, kalata B1...

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Peptide Synthesis

Peptide Synthesis

In this recent Science publication, Hartrampf et al. report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing of peptide chains up to 164 amino acids long...

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Cyclotide Production

Cyclotide Production

In this manuscript researchers in Dr. Craik's lab describe a strategy to improve the production of cyclotides, which are usually produced and cyclized synthetically at a high cost and environmental impact for large scale.

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Improved Thiol Protection

Improved Thiol Protection

Photoremovable caging groups are useful for biological applications because the deprotection process can be initiated by illumination with light without the necessity of adding additional reagents...

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Peptide Self Assembly

Peptide Self Assembly

Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes...

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Peptide Mimics

Peptide Mimics

Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications...

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γ-Amino Acids Elongation

γ-Amino Acids Elongation

Because γ-amino acids generally undergo rapid self-cyclization upon esterification on the carboxyl group, for example, γ-aminoacyl-tRNA, there are no reports of the ribosomal elongation...

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Nanosheet Fabrication

Nanosheet Fabrication

Engineering free-standing 2D nanomaterials with compositional, spatial, and functional control across size regimes from the nano- to mesoscale represents a significant challenge....

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Hydrophobic Moieties

Hydrophobic Moieties

Trans amide bonds and fast cis–trans isomerization of Xaa-Pro bonds are crucial for the stability and folding rate of collagen, the most abundant protein in mammals...

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Platinum Nanoparticles

Platinum Nanoparticles

Hepatocellular carcinoma, HCC, is the sixth most frequent cancer and the second leading cause of death from cancer worldwide. Sorafenib is the most commonly used FDA‐approved systemic...

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Ice Nucleators

Ice Nucleators

In a manuscript published in Langmuir, Yuki Kamijo and Ratmir Derda from the, University of Alberta, describe a screening system that employs the difference...

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Ghost Peptides

Ghost Peptides

A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Published in ACS Chemical Biology, and presented...

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Octreotide Analogs

Octreotide Analogs

Somatostatin, SS, is a cyclic tetradecapeptide able to inhibit the release of growth hormone, GH, mainly through the binding to two G‐protein coupled...

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Enzyme Sequestration

Enzyme Sequestration

Liquid-like droplets of biomacromolecules are emerging as a fundamental mechanism of cellular signaling, but designing synthetic mimics to form such...

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Short Peptides

Short Peptides

Helical secondary and tertiary motifs are commonly observed as binding epitopes in natural and engineered protein scaffolds. While several strategies...

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Roads to Rome

Roads to Rome

Ribosomally synthesized and post-translationally modified peptides, RiPPs, are ubiquitous natural products. Bioactive RiPPs are produced from a precursor...

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Azapeptide Libraries

Azapeptide Libraries

Aza‐propargylglycine, azaPra, peptides are branching points for the synthesis of azapeptide libraries. Researchers in the Lubell Lab, published in...

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Unprotected Peptides

Unprotected Peptides

Ring-closing metathesis, RCM, is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected...

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Recent FASEB Updates

Recent FASEB Updates

Updated 5/9/21 Read about recent things happening at FASEB, a coalition of scientific societies including APS, that represents over 130,000 biological and biomedical researchers from around the world.