Lehigh University Department of Chemistry (Bethlehem, PA)
The Postdoctoral Research Associate will work as part of a team of scientists to design and synthesize small molecules, peptides, or express proteins that label live bacterial cells. The focus is primarily on synthetic components and analysis in bacterial cells. Research duties will include protein expression and purification from bacteria and subsequent modification (bioconjugation) and peptide synthesis in solution phase and/or solid phase. Responsibilities may include bacterial cell-based assay development and optimization, elucidation of biologically relevant targets/mechanisms of action, flow cytometry analysis, and confocal microscopy. Postdoctoral Fellow will publish their findings in high impact, peer-reviewed journals and be co-inventors on patents related to their work.
The Pires research group has recently demonstrated that several cell wall biosynthetic enzymes display broad substrate promiscuity. They are one of the few groups in the world with the expertise to assemble molecules that exploit these enzymes to decorate bacterial cell surfaces and their precursors by direct metabolic incorporation. Their research team has pioneered a novel strategy to graft haptens onto bacterial surfaces to recruit endogenous antibodies with the ultimate goal of enlisting the immune system to clear bacterial infections. Moving forward, the Pires laboratory will develop a transformative class of cell wall probes that reveal key features of cell wall sensing and remodeling dynamics in live cells. Their advances in this area demonstrate that their research team can be highly competitive as they expand their methodologies to elucidate how bacterial cell walls are detected by the human immune system and how cell wall structural modifications control bacterial drug resistant phenotypes.
Applicants, please send your curriculum vitae, representative publications, and three names of references (letters of reference upon request). For additional information contact Dr. Marcos Pires, Department of Chemistry, Lehigh University firstname.lastname@example.org. Review of applications will begin immediately and will continue until the position is filled.
For more information on our research, please visit https://www.lehigh.edu/~map311/index.html
Start dates can be negotiated.
REQUIRED QUALIFICATIONS AND EXPERIENCE:
Ph.D. and previous experience working with peptide synthesis, protein expression, and some experience with bacterial culture.
Ashok Khatri Lab/Endocrine Unit Peptide/Protein Core Facility/ Massachusetts General Hospital
Massachusetts General Hospital (Harvard Medical School)
Torrey Pines Institute of Molecular Studies and Florida International Univeristy