Job Postings

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Postdoctoral Fellow (Pires Lab)

Lehigh University Department of Chemistry (Bethlehem, PA)

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Business Development Manager/ Senior Manager

CPC Scientific

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Scientist / Chemist, Instrumentation

CSBio

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Research Laboratory Technician

Ashok Khatri Lab/Endocrine Unit Peptide/Protein Core Facility/ Massachusetts General Hospital

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Postdoctoral Fellow (Russell and Khatri Lab)

Massachusetts General Hospital (Harvard Medical School)

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Faculty Positions Available

Torrey Pines Institute of Molecular Studies and Florida International Univeristy

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Scientist / Chemist, Instrumentation

CS Bio

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Senior Scientist, Biotherapeutics

Celgene

Job Description
Req #: 1901806
Location: San Diego, California, United States
Job Category: Research and Early Development
Work Location: 4242 Campus Point Court 92121
Organization: Biology
Employee Status: Full-time
Job Type: Regular
Celgene’s Biotherapeutics group is looking to add a Senior Scientist to our Discovery site in San Diego .  This position is a laboratory-based position which will be responsible for supporting the Bio-therapeutics discovery and molecular/developability assessment activities.

What great looks like in this role:

Our ideal candidate will be a highly motivated Scientist ready to work within a science-focused, collaborative, and multidisciplinary drug research and development environment.  You have demonstrated expertise in protein engineering with focus on purification and characterization ofprotein therapeutics including antibodies, bispecific antibodies and antibody-drug conjugates (ADCs).  You are excited about advancing product/process understanding and promotion of innovative approaches to support both late-stage discovery and drug development activities. 

Primary responsibilities:

Collaboration with project teams, outside partners, contract research/manufacturingorganizations and other functions within Discovery and Development groups will be expected.  Additional duties will include:


Design and implement experiments for the purification and analytical characterization of therapeutic proteins, antibodies and ADCs.
Support therapeutic protein (including) antibody design, engineering and ADC for cyno PK and exploratory toxicology.
Work in close collaboration with formulation and discovery scientists and Biologics development scientists.
Be a hands-on presence in the laboratory.
Specify, purchase, install and maintain analytical equipment for the Biologics laboratory in San Diego.
Manage a group of scientists and associates.  Recruit and hire additional analytical professionals as portfolio demands dictate. Provide technical guidance, Supervise and develop scientific staff.
Serve on and lead departmental, interdepartmental and project teams as required.
Write formal technical reports, methods and procedures.
Train personnel on use of equipment and methods.
Adhere to all relevant compliance requirements.

Required Qualifications:

Ph.D. in Analytical Chemistry, Biochemistry or relevant discipline. Candidates with an M.S. or B.S. in the same fields will also be considered with minimum lab experience of 8 and 10+ years, respectively.
At least 6 years of work experience within the life sciences industry is required
Comprehensive knowledge of therapeutic proteins/antibodies and ADC analytics and characterization for regulatory filings.
A demonstrated record of scientific accomplishment, laboratory experimentation, publications and presentations.
Extensive laboratory experience with and an in-depth knowledge of analytical method development and implementation including:  HPLC (RP, SEC, IEC, NP, and HIC), capillary electrophoresis (CE), capillary isoelectric focusing (cIEF), and glycan analysis.
Must possess extensive experience and understanding of mass spectrometric techniques particularly with developing and implementing LC-MS methods using TOF and Orbi-trap instruments for intact mass analysis, reduced and non-reduced peptide map analysis.  (experience with Thermo LTQ  series preferred)
Demonstrated management/leadership skills
Strong problem-solving and troubleshooting skills.  A working knowledge of the repair and maintenance of standard analytical equipment is desired
Strong capabilities in experimental design, execution and data interpretation.
Ability to work independently.
Ability to provide scientific guidance, leadership and training to others within/outside the department.
Strong verbal and written communication skills.

Preferred Qualifications
Experience with modern laboratory automation.
Familiarity with Quality by Design
Biophysical characterization techniques including spectroscopy (UV/Vis, CD, fluorescence, FTIR), calorimetry (DSC, ITC), light scattering (static and dynamic LS), analytical ultracentrifugation
Familiarity with ELISA, BIAcore, Octet

https://jobs.celgene.com/jobs/POSTING-3-12220?lang=en-us

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Research Associate, Peptide Synthesis & Analysis

Ferring Pharmaceuticals

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Project Chemist

Bachem

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Contract Peptide Chemist

Genentech

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Current Issue

The aim of Peptide Science is to publish significant original research papers and up-to-date reviews covering the entire field of peptide research. Peptide Science provides a forum for papers covering all aspects of peptide synthesis, materials, structure and bioactivity, including the use of peptides in exploring protein functions and protein-protein interactions.

Recent FASEB News


The FASEB Science Policy Committee met recently and the following are two items of potential interest to APS members:

FASEB Submits Testimony to Congress on FY 2020 Funding for Research Agencies

FASEB Statement on Bipartisan Effort to Increase the Budget Caps