Organic Synthesis and Peptide Synthesis

Two Positions in Organic Synthesis and Peptide Synthesis at UC Davis

Positions: New funding is immediately available for two full time positions in Organic Synthesis and Peptide Synthesis in the Department of Pharmacology.

Project: Successful candidates will synthesize different dyes that work as fluorescent molecular rotors. They will utilize One Bead One Compound (OBOC) technology developed by our collaborator Dr. Kit Lam (Nature 354, 82-84) to create and screen for peptides with FMR for instant detection of defined proteins in neurons.

Background: FMRs only fluoresce when in viscous environment or, as pursued here, bound to target proteins. The focus will be on developing peptides with FMRs that specifically bind to one of several proteins in neurons including AMPA- and NMDA-type glutamate receptors, Ca channels, and structural proteins such as PSD-95. We study their regulation and function with cutting edge biochemical, cell biological (superresolution microscopy), electrophysiological, and genetic/behavioral methods (e.g., Science 293,98; Science 293,2205; Science Signaling 10, eaaf9659; Nature 411,801; Neuron 74,1023; Neuron 78,483; Neuron 81,249; Neuron 88,528; EMBO J. 26,4879; EMBO J. 29,482; EMBO J. 31,1203; EMBO J. 33,1341; EMBO J. 35,1330; EMBO J. 37,122; Cell Rep 22, 2246; Neuron 97, 1094; Neuron 98, 783).

Candidates will have several years of expertise in Organic or Peptide Synthesis. They will work as members of a highly interactive and collegial team. Each team member is responsible for 1-2 defined projects. Application of newly developed FMR peptides to determine protein localization and live trafficking with superresolution microscopy is an option.

Depending on qualification and years of experience candidates will be considered for a postdoctoral or potentially more senior position (e.g., Project Scientist).

Please e-mail applications by to Dr. Johannes W. Hell (jwhell@ucdavis.edu).

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