Two Full-time Positions, Organic Synthesis and Peptide Synthesis
Two Positions in Organic Synthesis and Peptide Synthesis at UC Davis
Positions: New funding is immediately available for two full time positions in Organic Synthesis and Peptide Synthesis in the Department of Pharmacology.
Project: Successful candidates will synthesize different dyes that work as fluorescent molecular rotors (FMRS). They will utilize One Bead One Compound (OBOC) technology developed by our collaborator Dr. Kit Lam (Nature 354, 82-84) to create and screen for peptides with FMR for instant detection of defined proteins in neurons. Additional technology will involve metal-enhanced fluorescence (MEF).
Background: FMRs only fluoresce when in viscous environment or, as pursued here, bound to target proteins. The focus will be on developing peptides with FMRs that specifically bind to one of several proteins in neurons including AMPA- and NMDA-type glutamate receptors, Ca channels, and structural proteins such as PSD-95. We study their regulation and function with cutting edge biochemical, cell biological (superresolution microscopy), electrophysiological, and genetic/behavioral methods (e.g., Science 293,98; Science 293,2205; Science Signaling 10, eaaf9659; Nature 411,801; Neuron 74,1023; Neuron 78,483; Neuron 81,249; Neuron 88,528; EMBO J. 26,4879; EMBO J. 29,482; EMBO J. 31,1203; EMBO J. 33,1341; EMBO J. 35,1330; EMBO J. 37,122; Cell Rep 22, 2246; Neuron 97, 1094; Neuron 98, 783). Most recently we are also targeting COVID19 spike protein to develop a rapid detection method in combination with MEF.
Candidates will have expertise in Organic or Peptide Synthesis. They will work as members of a highly interactive and collegial team. Each team member is responsible for 1-2 defined projects. Application of newly developed FMR peptides to determine protein localization and live trafficking with superresolution microscopy is an option.
Depending on qualification and years of experience candidates will be considered for a postdoctoral or potentially more senior position (e.g., Project Scientist).
Please e-mail applications by to Dr. Johannes W. Hell (firstname.lastname@example.org).
Please join us for the 27th American Peptide Symposium to be held June 12-17, 2021 in the beautiful mountain town of Whistler, Canada. The meeting program will cover a broad range of peptide-related topics and provides an excellent opportunity to network and collaborate with scientists from around the world.
Buyan Pan is one of the winners of the Peptide Science Poster Awards at the 2019 American Peptide Symposium in Monterey, CA...