Senior Medicinal Chemist

Senior Medicinal Chemistry Project Lead – Staff Scientist
Position Description:
The Center for Cancer Research (CCR), National Cancer Institute employs nearly 250 basic and clinical research
groups located on two campuses outside of Washington, DC. The CCR is grounded in an exceptionally strong
discovery research program that leads to transformative clinical applications and patient care. One of our
most important goals is to advance translational bench findings into clinical trials. To further strengthen this
effort, the CCR is hiring two Senior Medicinal Chemists to serve as Project Leads who will manage the
preclinical development and translation of small molecules discovered from Principal Investigator-initiated
high-throughput screening, computational and structural biology campaigns.
The Project Lead positions offer a unique opportunity to design and advance the strategy and execution of a
portfolio of projects by planning and managing medicinal chemistry efforts. These projects will include
potency optimization, DMPK/ADME and TOX studies primarily performed by contract research organizations
(CROs). Project Leads will have the opportunity to lead medicinal chemistry efforts while working directly with
CCR Principal Investigators, as well as be instrumental members of an oversight committee that provides
status and resource allocation recommendations to CCR senior staff for projects in their portfolio.
Key Responsibilities:
• Design and execute development strategies for small molecules from lead generation into clinical
candidates
• Initiate, manage and interpret data generated from CROs
• Design new chemical entities to improve potency, selectivity, and activity in preclinical animal models
including DMPK/ADME TOX
• Present data and make project recommendations to CCR senior staff
The positions are located at the NCI-Frederick Maryland campus and associated with the Chemical Biology
Laboratory (https://ccr.cancer.gov/chemical-biology-laboratory). The NCI-Frederick campus is rich in physical
sciences, including RNA Biology, Structural Biology, High-Throughput Screening, Natural Products Discovery
and Chemistry, providing a dynamic environment and strong support network for chemical discovery and
development.
Qualifications:
Candidates must have a Ph.D. in chemistry or related discipline with a strong background in small molecule
synthesis/development/medicinal chemistry, at least five years of pharmaceutical industrial experience,
experience working with CROs, and possess outstanding interpersonal and communication skills. Salary will be
commensurate with experience and accomplishments. This position is not restricted to U.S. citizens. A full civil
service package of benefits (including health insurance, life insurance, and retirement) is available.

The CCR has developed a careful approach to partial reopening in the current pandemic that has minimized
staff COVID-19 cases and enabled vital research to continue. This position will be filled, and work initiated
without delay, in compliance with safety regulations.
To Apply:
Please send a cover letter including a career synopsis (1-3 pages), curriculum vitae and bibliography, and
names and contact information of three references in one .pdf file to:
Patricia Beard by email
E-mail address: beardp@mail.nih.gov
Applications must be received on or before January 15, 2021 for consideration.
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in
its training and employment programs.

DHHS and NIH are Equal Opportunity Employers

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